ABSTRACT
Aims: The present study was carried out to evaluate the effects of Xylopia aethiopica on serum lipids in fed rats. Also the quantitative phytochemical and nutrient composition was investigated. Study Design: Quantitative phytochemical, proximate analysis and in vivo effect on serum lipid profile. Place and Duration of Study: Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike Abia State, between June 2013 and September 2013. Methodology: The fruit were cut into small piece, dried and ground into powder. The quantitative phytochemical and proximate nutrient analyses of the powder sample were determined using standard methods. The serum lipid lowering effects of the powdered fruit in rats was determined by feeding different groups of rats with graded levels (5, 10, 20 and 50%) of the powdered fruit incorporated in their feed for 21 consecutive days and the effects on the total cholesterol, triglyceride, LDL-C, and HDL-C were compared with a negative control. Results: The fruit sample produced significant (p<0.05) concentration-dependent decrease in the total serum cholesterol, triglyceride, LDL-C and VLDL-C levels and increase in serum HDL-C level in fed groups of rats when compared to the control group. The phytochemical analysis showed that the sample contained tannins (4.96%), flavonoids (0.81%), saponins (2.93%) and alkaloids (1.24%). The proximate analysis of the nutrient composition of powdered Xylopia aethiopica sample showed the presence of moisture, lipid, crude fibre, crude protein, ash and nitrogen free extracts in the following proportion 6.32, 12.54, 14.51, 0.91, 2.31 and 63.41% respectively. Conclusion: The fruit sample demonstrated good hypolipidemic effects which may suggest that the consumption of Xylopia aethiopica fruit may help in the reduction of the incidence of hyperlipidemia related diseases in patients.